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*                        EX2f.mlxtran                                          *
*                        September 16, 2024 at 13:38:01                        *
*                        Monolix version : 2024R1                              *
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ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
V_pop            :                    31.6      1.12      3.56      29.5      33.9
beta_V_SEX_1     :                       0
beta_V_logAGE50  :                    -0.1
beta_V_logWT70   :                       1
Cl_pop           :                    2.76     0.077      2.79      2.62      2.92
beta_Cl_SEX_1    :                       0
beta_Cl_logAGE50 :                  -0.542     0.103      18.9    -0.743    -0.341
beta_Cl_logWT70  :                    0.75

Standard Deviation of the Random Effects -
omega_V          :                   0.223    0.0307      13.8     0.171     0.291
omega_Cl         :                   0.172    0.0252      14.6      0.13     0.228

Correlations -----------------------------
corr_V_Cl        :                 -0.0853     0.201       235    -0.447     0.301

Error Model Parameters -------------------
b                :                   0.226    0.0147       6.5     0.199     0.257

Elapsed time (seconds):      2.3
Exploratory phase iterations:      197 (Autostop)
Smoothing phase iterations:        120 (Autostop)

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ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Distribution ------------
               min            Q1        median            Q3           max  shrinkage(%)
V  :          19.6          29.5          34.1          43.5          57.5            15
Cl :          1.61          2.57          2.97          3.36          5.13            17

Elapsed time (seconds):     0.45
Iterations:       73 (Autostop)

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Estimation of the individual parameters by Conditional Mode --------------------
               min            Q1        median            Q3           max  shrinkage(%)
V  :          18.5          29.3          33.6            42          57.8          15.9
Cl :          1.68          2.63          3.03          3.51          5.31          14.2

Elapsed time (seconds):    0.036

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
           V_pop         1
          Cl_pop  0.051455         1
beta_Cl_logAGE50 -0.048029  0.071249         1
         omega_V -0.021779 -0.080103 0.0046291         1
       corr_V_Cl -0.016352  0.063202  -0.12456   0.18024         1
        omega_Cl 0.0023198  -0.07451 -0.002443  0.056672  0.095431         1
               b   0.11832   0.11384 0.0094828  -0.23149   -0.1564  -0.24778         1

                               min       max   max/min
Eigen values           :      0.66       1.5       2.3

Elapsed time (seconds):     0.35
Iterations:       50 (Autostop)

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ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                            (is)
-2 x log-likelihood                       (OFV) :        1501.19
Akaike Information Criteria               (AIC) :        1515.19
Corrected Bayesian Information Criteria  (BICc) :        1534.01
Bayesian Information Criteria             (BIC) :        1529.85

Elapsed time                          (seconds) :           5.48
CPU time                              (seconds) :           5.00
MonteCarlo size (is):    10000 (Fixed number of iterations)


[Importance Sampling] Standard error        : 0.037
                      Sampling distribution : T-distribution with 5 degrees of freedom

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DATASET INFORMATION
Number of individuals: 60
Number of observations (DV): 240
Number of doses: 60

